September 1, 1988Angiology

Circulatory Effects of Intravenous and Oral Atenolol in Acute Myocardial Infarction

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Why the study?

Does intravenous or oral atenolol safely alter hemodynamic variables in men with acute uncomplicated myocardial infarction?

Structured PICO

Does intravenous or oral atenolol safely alter hemodynamic variables in men with acute uncomplicated myocardial infarction?

Population

n=24 men within 17 hours of an acute uncomplicated myocardial infarction.

Intervention

Atenolol administered as a single dose either intravenously (0.05 or 0.10 mg/kg) or orally (50 or 100 mg).

Comparator

Other doses and routes of atenolol (between-group comparison of IV vs oral and low vs high dose) following a 1-hour control period.

Outcome

Hemodynamic variables (heart rate, cardiac and stroke volume indices, pulmonary artery occluded pressure, systemic vascular resistance index, mean arterial pressure) measured up to 360 minutes.surrogate

Both intravenous and oral atenolol demonstrate similar peak hemodynamic effects and are hemodynamically safe when administered within 17 hours of an acute uncomplicated myocardial infarction.

Discussion

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Implication

Supports early atenolol in uncomplicated acute MI; confirms equivalent hemodynamic effects of IV and oral routes.

Cite This Study

Midtbo et al. (1988) studied this question.

synapsesocial.com/papers/6a7dd09d87be3f923b5ca556 https://doi.org/10.1177/000331978803900903

View Full Paper

Ask AI

Bookmark

Circulatory Effects of Intravenous and Oral Atenolol in Acute Myocardial Infarction

Structured PICO

Discussion

Implication

Cite This Study

Circulatory Effects of Intravenous and Oral Atenolol in Acute Myocardial Infarction

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider