Nifekalant Hydrochloride Suppresses Severe Electrical Storm in Patients With Malignant Ventricular Tachyarrhythmias

91 consecutive patients treated with an implantable cardioverter-defibrillator (ICD) for clinical documentation of VF, VT, or unexplained syncope, mean age 58 years, 77% male, mean LVEF 45%. 11 patients developed severe electrical storm (≥10 ICD discharges within 1 h).

Intravenous nifekalant hydrochloride (loading infusion of 0.1-0.3 mg/kg for 5 min, maintenance dose of 0.2-0.4 mg/kg/h) administered to patients with severe electrical storm refractory to deep sedation and beta-blockade.

Suppression of severe electrical storm (reduction in frequency of ICD discharges or cessation of VT/VF).hard clinical