Development of a novel method to determine very low density lipoprotein kinetics
Why the study?
Does a novel Intralipid infusion method accurately determine VLDL kinetics in healthy subjects?
Population
10 healthy subjects (7 men; fasting triglyceride 44.3-407.6 mg/dl; body mass index 21-35 kg/m2)
Follow-up
75-120 min infusion plus post-infusion sampling
Authors
Discussion
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Member takes
Implication
May enable simpler VLDL kinetic research; leaves open validation in patients before clinical use.
Structured PICO
Does a novel Intralipid infusion method accurately determine VLDL kinetics in healthy subjects?
P
Population
10 healthy subjects (7 men; fasting triglyceride 44.3-407.6 mg/dl; body mass index 21-35 kg/m2)
I
Intervention
Intravenous infusion of a chylomicron-like TG emulsion (Intralipid; 0.1 g/kg bolus followed by 0.1 g/kg/h infusion) for 75-120 min
O
Outcome
VLDL1-apolipoprotein B (apoB) and TG production rates, and Intralipid-TG clearance ratesurrogate
A novel, cost-effective Intralipid infusion method provides VLDL kinetic data that agree with traditional stable isotope methods.
Cite This Study
Al-Shayji et al. (2007) studied this question.