July 1, 1978The Journal of PhysiologyOpen Access

Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors.

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Population

Rabbit citrated platelet-rich plasma

Design

Preclinical

Authors

GBG. V. R. BornUniversity of London RDR Dearnley JFJames G. FoulksUniversity of British Columbia

Discussion

Member takes

Implication

Reversible ADP-driven platelet shape change without volume shift in animals; leaves open translation to human thrombosis models.

Structured PICO

Population

Rabbit citrated platelet-rich plasma

Intervention

Addition of aggregating agents (adenosine diphosphate [ADP] or 5-hydroxytryptamine [5-HT]) and antagonists (adenosine triphosphate, 2-chloroadenosine, or prostaglandin E1), or calcium chelating agents

Outcome

Morphological changes of platelets (shape changes, transformation of disks to spherical forms, extrusion of blebs and spikes) measured by photometric, volumetric techniques, and electron micrographssurrogate

Aggregating agents like ADP induce reversible morphological changes in platelets, including spike formation and spherical transformation, without altering intrinsic platelet volume.

Cite This Study

Born et al. (1978) studied this question.

synapsesocial.com/papers/6a7dd45b1ec832c82ccdb200 https://doi.org/10.1113/jphysiol.1978.sp012380

View Full Paper

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Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Quantification of the morphological reaction of platelets to aggregating agents and of its reversal by aggregation inhibitors.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider