August 1, 1970The Journal of PhysiologyOpen Access

Observations on the change in shape of blood platelets brought about by adenosine diphosphate

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Population

Dilute suspension of platelets with sufficient EDTA to prevent their aggregation

Design

Preclinical

Authors

GBG. V. R. BornUniversity of London

Discussion

Member takes

Implication

Supports ADP receptor characterization in platelets; leaves open translation to human antithrombotic targets.

Structured PICO

Population

Dilute suspension of platelets with sufficient EDTA to prevent their aggregation

Intervention

Adenosine diphosphate (ADP)

Outcome

Change in shape of platelets (velocity and magnitude of optical effects)surrogate

ADP induces platelet shape change via specific membrane receptors, a process that follows Michaelis-Menton kinetics and is competitively inhibited by ATP and adenosine.

Cite This Study

G. V. R. Born (1970) studied this question.

synapsesocial.com/papers/6a6ffdae660549caf2c48adc https://doi.org/10.1113/jphysiol.1970.sp009176

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Observations on the change in shape of blood platelets brought about by adenosine diphosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Observations on the change in shape of blood platelets brought about by adenosine diphosphate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider