Why the study?
Testing mechanical hypotheses on proteins in their natural tissue environment remains inaccessible to conventional tools.
The HaloTag-TEV genetic cassette enables the specific severing and mechanical manipulation of titin in its native tissue environment, revealing its significant contribution to muscle passive stiffness.
No takes yet. Share an insight, caveat, or question.
Mouse model enables native-environment titin mechanics testing; leaves open translation to human cardiac stiffness.
Rivas‐Pardo et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: