Why the study?
Does a single dose of cerivastatin improve flow-mediated dilatation of the brachial artery in healthy normocholesterolaemic subjects?
Does a single dose of cerivastatin improve flow-mediated dilatation of the brachial artery in healthy normocholesterolaemic subjects?
A single dose of cerivastatin rapidly and transiently improves endothelial function independent of lipid-lowering effects, suggesting direct pleiotropic vascular benefits.
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Supports acute pleiotropic endothelial benefits of statins independent of lipids; extends prior chronic data to single-dose effects in healthy subjects.
Omori et al. (2002) studied this question.
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