Why the study?
Does cerivastatin reduce monocyte adhesion to vascular endothelium in an in vitro model?
Population
In vitro model using monocytic U937 cells and activated human umbilical vein endothelial cells
Comparison
Cerivastatin incubation for 48 hours vs No statin treatment
Design
Preclinical
Follow-up
48 hours
Authors
Loading...
Supports pleiotropic anti-adhesive effects in vitro; leaves open translation to clinical outcomes.
Does cerivastatin reduce monocyte adhesion to vascular endothelium in an in vitro model?
Cerivastatin reduces monocyte adhesion to vascular endothelium via downregulation of integrin adhesion molecules and inhibition of actin polymerization, providing mechanistic insight into the lipid-independent pleiotropic effects of statins.
Yoshida et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: