March 1, 1999Clinical Chemistry and Laboratory Medicine (CCLM)
Effects of Oxidized Low Density Lipoprotein, Lipid Mediators and Statins on Vascular Cell Interactions
Key result
Treatment with statins decreased surface expression of Mac-1 and dramatically reduced Mac-1-mediated monocyte adhesion to endothelium in patients with hypercholesterolemia.
Why the study?
Do statins and lipid mediators affect Mac-1-dependent monocyte adhesion to endothelium?
Population
Endothelial cells, monocytes, polymorphonuclear leukocytes, platelets, and patients with hypercholesterolemia
Comparison
Statins, oxidized low density lipoprotein, and… vs Controls (for patient studies) and untreated cells
Design
Review
Authors
Discussion
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Member takes
Implication
May support statin anti-inflammatory effects beyond lipids; leaves open clinical outcome relevance in hypercholesterolemia.
Structured PICO
Do statins and lipid mediators affect Mac-1-dependent monocyte adhesion to endothelium?
P
Population
Endothelial cells, monocytes, polymorphonuclear leukocytes, platelets, and patients with hypercholesterolemia
I
Intervention
Statins (HMG-CoA reductase inhibitors), oxidized low density lipoprotein (oxLDL), and lipid mediators
C
Comparator
Controls (for patient studies) and untreated cells
O
Outcome
Mac-1-mediated monocyte adhesion to endothelium and surface expression of Mac-1surrogate
Statins reduce Mac-1-mediated monocyte adhesion to endothelium via isoprenoid-dependent mechanisms, suggesting a cholesterol-independent anti-inflammatory effect that may contribute to their clinical benefit.
Cite This Study
Weber et al. (1999) conducted a review in Hypercholesterolemia. Statins vs. Controls was evaluated on Mac-1-mediated monocyte adhesion to endothelium. Treatment with statins decreased surface expression of Mac-1 and dramatically reduced Mac-1-mediated monocyte adhesion to endothelium in patients with hypercholesterolemia.