The requirement for priming for beta-interferon induction by double-stranded RNA cannot be localized to a specific sequence element in the promoter, suggesting priming induces an essential component for signal transduction.
Cell-specific priming for dsRNA interferon induction may not generalize; leaves open the identity of the induced transduction component.
The induction of beta-interferon is markedly enhanced in some cell types by a pretreatment with type I interferon itself (priming). We show that induction in response to double-stranded RNA is completely dependent upon priming in HeLa cells. However, unprimed cells can be partially induced by Sendai virus. This indicates that Sendai virus can provide a signal that is different from, or additional to, that provided by double-stranded RNA. The requirement for priming cannot be localized to a specific sequence element in the beta-interferon promoter, suggesting that priming may induce an essential component for signal transduction in response to double-stranded RNA.
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King et al. (1994) studied this question.
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