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February 1, 1996Journal of Interferon & Cytokine Research

Relative Transcriptional Inducibility of the Human Interferon-α Subtypes Conferred by the Virus-Responsive Enhancer Sequence

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Population

Namalwa cells infected with Sendai virus

Design

Preclinical

Authors

CDCarolyn L. DentBristol Robotics LaboratorySMSONYA J. MACBRIDENSNigel A. SharpGlaxoSmithKline (United Kingdom)

Discussion

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Overview

These cell-line results support further study of interferon transcriptional control; leaves open in vivo or clinical relevance.

Structured PICO

P
Population
Namalwa cells infected with Sendai virus
I
Intervention
Reporter gene constructs with virus-response elements from IFNA1, A2, A4, and A14 subtype genes
O
Outcome
Relative abundance of mRNA species and inducibility of reporter gene constructssurrogate

Transcriptional control plays a key role in determining the levels of individual interferon-alpha subtypes secreted following viral infection, and the selection drug G418 reversibly inhibits this induction.

Cite This Study

Dent et al. (1996) studied this question.

synapsesocial.com/papers/6a8310fb8847014bd698ffaehttps://doi.org/10.1089/jir.1996.16.99
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes1991 · 37 citations
  2. 2Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1.1993 · 83 citations
  3. 3Upstream Regulatory Elements of Murine α4-Interferon Gene Confer Inducibility and Cell Type-restricted Expression1989 · 35 citations
  4. 4Induction of interferon alpha genes expression1995 · 31 citations