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June 1, 1989Journal of Interferon Research

The Role of the Various Human Peripheral Blood Mononuclear Cells in the Production of Sendai Virus-Induced Interferon: IFN mRNA Studies

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Population

Human peripheral blood mononuclear cells (in vitro)

Design

Preclinical

Authors

IRI RosztóczyUniversity of SzegedMPMiklós PapósUniversity of Szeged

Discussion

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Overview

May inform leukocyte-targeted antiviral approaches; leaves open clinical translation from animal models.

Structured PICO

P
Population
Human peripheral blood mononuclear cells (in vitro)
I
Intervention
Sendai virus induction
O
Outcome
Amount of interferon (IFN) produced, proportion of IFN-producing cells, and content of IFN mRNAsurrogate

Monocytes and E rosette-negative lymphocytes are the primary producers of interferon in human peripheral blood mononuclear cells following Sendai virus induction.

Cite This Study

Rosztóczy et al. (1989) studied this question.

synapsesocial.com/papers/6a886233dea5055e4b609650https://doi.org/10.1089/jir.1989.9.349
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytochemical Identification of Monocytes and Granulocytes1971 · 2,694 citations
  2. 2Characterization of Non-T Effector Cell Subpopulations Involved in Production of Human Alpha Interferon1986 · 2 citations
  3. 3Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.1981 · 147 citations
  4. 4Human Monocytes and Lymphocytes Produce Different Mixtures of α-Interferon Subtypes1986 · 23 citations
  5. 5Characterization of interferons induced by bacteria and interferon-producing leukocytes in human peripheral blood1983 · 42 citations