Key result
Sendai and attenuated measles viruses induce considerable interferon in human cells unlike virulent strains.
Why the study?
The capacity of Sendai and measles viruses to induce interferon in human lymphoblastoid cells was investigated to understand their differential effects.
Population
Human lymphoblastoid cells
Comparison
Sendai virus vs Edmonston-Enders measles virus strains (attenuated and virulent), with or without IdUrd pre-treatment or UV inactivation
Design
Preclinical experimental study
Authors
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Strain-specific interferon induction in lymphoblastoid cells remains hypothesis-generating; leaves open in vivo relevance and clinical translation.
Sendai and attenuated measles viruses are effective inducers of interferon in human lymphoblastoid cells, whereas virulent measles virus is not.
Volckaert-Vervliet et al. (1977) studied this question. Sendai and measles viruses was evaluated on Interferon induction. Sendai virus and the attenuated Edmonston-Enders strain of measles virus induced considerable amounts of interferon in human lymphoblastoid cells, whereas the virulent strain induced minimal amounts.
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