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January 1, 1982Journal of General Virology

Control of Interferon mRNA Levels and Interferon Yields in Butyrate and 5'-Bromodeoxyuridine-treated Namalwa Cells

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Population

Namalwa cells

Design

Preclinical

Authors

JSJames ShuttleworthSouthport and Ormskirk Hospital NHS TrustJMJohn MorserCross-Cutting CardiologyDBD. C. BurkeUniversity of East Anglia

Discussion

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Implication

Does not support clinical use of butyrate or BrdUrd to boost IFN; leaves open transcriptional-translational mechanisms for future antiviral studies.

Structured PICO

P
Population
Namalwa cells
I
Intervention
Treatment with butyrate or 5'-bromodeoxyuridine (BrdUrd) before induction with Sendai virus
O
Outcome
Interferon (IFN) production and interferon mRNA (IFN mRNA) levelssurrogate

Butyrate and BrdUrd enhance interferon production in Namalwa cells through effects on transcription/processing and increased translation efficiency.

Cite This Study

Shuttleworth et al. (1982) studied this question.

synapsesocial.com/papers/6a912cfd57cb38abaad2c1f9https://doi.org/10.1099/0022-1317-58-1-25
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Low Temperature Treatment of Namalwa Cells Causes Superproduction of Interferon1981 · 11 citations