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July 1, 1978Journal of General Virology

Effect of Interferon on Mouse Cells Chronically Infected with Murine Leukaemia Virus: Kinetic Studies on Virus Production and Virus RNA Synthesis

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Why the study?

Does interferon inhibit virus production in NIH/3T3 cells chronically infected with murine leukaemia virus?

Population

NIH/3T3 cells chronically infected with the Moloney strain of murine leukaemia virus

Comparison

Interferon (IF) incubation vs Untreated state

Design

Preclinical

Follow-up

Up to 72 hours

Authors

SSSamuel SalzbergBar-Ilan UniversityMBMary BakhanashviliBar-Ilan UniversityMAM. AboudBen-Gurion University of the Negev

Discussion

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Implication

May block late-stage murine leukemia virus maturation in vitro; hypothesis-generating for retroviral mechanisms, leaves open in vivo relevance.

Structured PICO

Does interferon inhibit virus production in NIH/3T3 cells chronically infected with murine leukaemia virus?

P
Population
NIH/3T3 cells chronically infected with the Moloney strain of murine leukaemia virus
I
Intervention
Interferon (IF) incubation
C
Comparator
Untreated state (implied by normal rate of virus release)
O
Outcome
Kinetics of virus production and virus RNA synthesissurrogate

Interferon appears to inhibit a late stage in the maturation of murine leukaemia virus in chronically infected cells.

Cite This Study

Salzberg et al. (1978) studied this question.

synapsesocial.com/papers/6a95bbb6c992b03bd554fb06https://doi.org/10.1099/0022-1317-40-1-121
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of interferon on the synthesis of virus particles in oncornavirus carrier cell lines. III. Survey of effects on A‐, B‐ and C‐type oncornaviruses1975 · 32 citations
  2. 2Purification of Mouse Interferon by Affinity Chromatography on Anti-Interferon Globulin-Sepharose1973 · 118 citations
  3. 3Isolation and characterization of DNA-DNA and DNA-RNA hybrid molecules formed in solution1977 · 27 citations
  4. 4Inhibition of Murine Leukemia Virus Production in Chronically Infected AKR Cells: A Novel Effect of Interferon1974 · 96 citations
  5. 5Synthesis and cleavage processing of oncornavirus proteins during interferon inhibition of virus particle release1977 · 21 citations