Interferon treatment does not inhibit virus-specific RNA synthesis in mouse cells infected with Moloney murine leukemia virus.
Interferon does not inhibit MuLV RNA synthesis in murine cells; leaves open post-transcriptional mechanisms for further study.
Mouse cells productively infected with Moloney murine leukemia virus were treated with interferon, and intracellular virus-specific RNA was studied by hybridization with complementary DNA. The steady-state concentration of virus-specific RNA in interferon-treated cells was somewhat greater than that in untreated cells, and the rates of virus-specific RNA synthesis were approximately equal in treated and untreated cells.
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Fan et al. (1978) studied this question.
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