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February 1, 1981Journal of VirologyOpen Access

Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells

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Population

Two subclones of Swiss mouse cells infected with Moloney murine leukemia virus and NIH 3T3 cells infected…

Design

Preclinical

Authors

CCChristine W. CzarnieckiTulane UniversityTST. SreevalsanLourdes HospitalRFRobert M. FriedmanOregon National Primate Research Center

Discussion

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Implication

Indicates distinct IFN mechanisms for MuLV inhibition; leaves open applicability to other viruses or in vivo models.

Structured PICO

P
Population
Two subclones of Swiss mouse cells infected with Moloney murine leukemia virus (M-MuLV) and NIH 3T3 cells infected with M-MuLV
I
Intervention
Interferon (IFN)
O
Outcome
M-MuLV production, encephalomyocarditis (EMC) virus replication, and anticellular activitiessurrogate

Interferon affects cell growth functions and EMC replication through mechanisms different from those by which MuLV production is inhibited.

Cite This Study

Czarniecki et al. (1981) studied this question.

synapsesocial.com/papers/6a9183ef80800acc72340fdfhttps://doi.org/10.1128/jvi.37.2.827-831.1981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Interferon on Cell and Virus Growth in Transformed Human Cell Lines1976 · 75 citations
  2. 2QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES1963 · 2,781 citations
  3. 3Binding of tRNA to Reverse Transcriptase of RNA Tumor Viruses1978 · 57 citations
  4. 4Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture1977 · 118 citations
  5. 5Rapid quantitation of interferon with chronically oncornavirus-producing cells1976 · 41 citations