July 1, 1993Journal of VirologyOpen Access

Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus

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Population

Sera from patients with chronic hepatitis C (including two patients analyzed for antibody kinetics)

Design

Preclinical

Follow-up

several months

Authors

Discussion

Sequence-specific anti-HVR1 immunity may drive HCV evolution; leaves open human translation and therapeutic targeting.

Population

Sera from patients with chronic hepatitis C (including two patients analyzed for antibody kinetics)

Intervention

Immunoprecipitation assay using an HVR1 (27-amino-acid) dihydrofolate reductase fusion protein synthesized by in vitro transcription and translation

Outcome

Humoral immune response to HVR1 (production of sequence-specific antibodies)surrogate

Anti-HVR1 antibodies are sequence-specific and appear to be involved in the genetic drift of HVR1 by immunoselection in chronic HCV infection.

Kato et al. (1993) studied this question.

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