Population
Virus isolated during the acute and chronic phases of hepatitis in one patient (n=1)
Design
Preclinical
Follow-up
From acute to chronic phase of hepatitis
Authors
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HVR1 escape may contribute to HCV persistence in this model; leaves open whether conserved epitopes can inform human vaccine strategies.
The study demonstrates that genetic drift in the HVR1 region of HCV allows the virus to escape preexisting host antibodies, contributing to persistent infection.
Kato et al. (1994) studied this question.
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