Why the study?
Does adrenergic receptor stimulation induce cardiac hypertrophy via ROS production in neonatal rat cardiomyocytes?
Population
Neonatal rat cardiomyocytes
Design
Preclinical
Authors
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Hypothesis-generating in neonatal rat cardiomyocytes; leaves open translation to human adrenergic remodeling.
Does adrenergic receptor stimulation induce cardiac hypertrophy via ROS production in neonatal rat cardiomyocytes?
Proteomic profiling reveals that adrenergic receptor-mediated cardiac hypertrophy in neonatal rat cardiomyocytes is driven by ROS production and subsequent ERK1/2 activation.
Li et al. (2009) studied this question.
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