Population
In vitro model using smooth muscle myosin and bacterially expressed Kinase-related protein truncation mutants
Design
Preclinical
Authors
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Elucidates KRP-myosin binding in vitro; hypothesis-generating for smooth muscle regulation with no clinical implications yet.
The study identifies the specific regions of interaction between KRP and smooth muscle myosin, demonstrating that the acid-rich sequence of KRP is required for high-affinity binding and stabilization of myosin filaments.
Silver et al. (1997) studied this question.
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