Population
Dihydropyridine-sensitive Ca2+ channels from skeletal muscle
Comparison
Phosphorylation by cAMP-dependent protein… vs Unphosphorylated state or comparison between…
Design
Preclinical
Authors
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Animal data preclude clinical application; leaves open selective PKA/PKC effects on Ca2+ channels in intact muscle or disease models.
Phosphorylation of skeletal muscle dihydropyridine-sensitive Ca2+ channels by PKA and PKC, but not CaM or endogenous kinases, activates the channels by increasing Ca2+ influx.
Chang et al. (1991) studied this question.
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