November 5, 2021European Heart Journal
The Cardiology Society of India-Kerala Acute Heart Failure Registry: poor adherence to guideline-directed medical therapy
Why the study?
Data on the burden of acute heart failure admissions, practice patterns, and outcomes are rare from India and other low- and middle-income countries.
Is guideline-directed medical therapy associated with reduced 90-day mortality in patients admitted with acute heart failure in India?
Population
7507 patients admitted with AHF across 50 hospitals in Kerala, India
Design
Multicenter prospective observational registry
Follow-up
90-day
Authors
Discussion
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Member takes
Implication
GDMT use was associated with lower 90-day mortality in Indian acute HFrEF; leaves open whether optimization improves outcomes.
Structured PICO
Is guideline-directed medical therapy associated with reduced 90-day mortality in patients admitted with acute heart failure in India?
P
Population
7,507 patients admitted with acute heart failure (AHF) based on 2016 ESC criteria, mean age 64.3 years, 37% female, 67.5% with reduced ejection fraction, from 50 hospitals in Kerala, India.
I
Intervention
Guideline-directed medical therapy (GDMT)
C
Comparator
Non-prescription or partial prescription of GDMT components
O
Outcome
In-hospital and 90-day mortalityhard clinical
This large Indian registry highlights a significant gap in guideline-directed medical therapy prescription for acute heart failure, which is associated with high 90-day mortality.
Cite This Study
Joseph et al. (2021) studied this question.