Why the study?
Heart failure epidemiology in India remains largely unexplored, with existing data limited to a few North Indian registries.
What are the clinical characteristics and in-hospital outcomes of patients admitted with acute heart failure in South India?
Population
449 patients admitted with acute heart failure in South India
Comparison
HFrEF vs HFmrEF vs HFpEF
Design
Single-center hospital-based registry
Key result
In patients admitted with acute heart failure, in-hospital mortality was comparable across ejection fraction groups (1.6% HFrEF, 3.3% HFmrEF, 1.5% HFpEF), but significantly higher in those presenting with a cold and wet clinical phenotype (25%).
Authors
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Cold-wet phenotype flags high in-hospital mortality in acute HF irrespective of EF; hypothesis-generating for phenotype-guided risk models pending prospective validation.
Observational (n=449)
No
What are the clinical characteristics and in-hospital outcomes of patients admitted with acute heart failure in South India?
p-value: p=0.137
In a South Indian acute heart failure registry, HFrEF was the most common presentation, and the cold and wet clinical phenotype was associated with higher in-hospital mortality and worsening renal function.
Shukkoor et al. (2021) conducted an observational in Acute heart failure (n=449). Ejection fraction categories (HFrEF, HFmrEF, HFpEF) vs. Compared among groups was evaluated on In-hospital mortality (p=0.137). In patients admitted with acute heart failure, in-hospital mortality was comparable across ejection fraction groups (1.6% HFrEF, 3.3% HFmrEF, 1.5% HFpEF), but significantly higher in those presenting with a cold and wet clinical phenotype (25%).