Why the study?
Sevoflurane is reputed to protect against myocardial ischemia-reperfusion injury, but existing evidence remains inconclusive.
Does sevoflurane administration (pretreatment, preconditioning, or postconditioning) reduce myocardial ischemia-reperfusion injury in rat or mouse models?
Comparison
Sevoflurane pretreatment, preconditioning, or postconditioning vs nontreated controls
Design
Systematic review and meta-analysis
Authors
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Sevoflurane preconditioning reduces infarct size in animal I/R models; supports clinical translation trials but should not yet alter practice.
Does sevoflurane administration (pretreatment, preconditioning, or postconditioning) reduce myocardial ischemia-reperfusion injury in rat or mouse models?
In animal models of myocardial ischemia-reperfusion injury, sevoflurane administration before or after ischemia significantly reduces infarct size and improves cardiac function, supporting its potential cardioprotective utility during surgery.
Nasiri-Valikboni et al. (2024) studied this question.
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