Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats
Key result
Sevoflurane preconditioning attenuated systolic and diastolic dysfunction, preserved vagal modulation of heart rate variability, and reduced infarct size in rats after myocardial ischemia-reperfusion.
Why the study?
Does sevoflurane preconditioning improve cardiac function and autonomic modulation in rats undergoing myocardial ischemia-reperfusion?
Population
20 Wistar rats subjected to myocardial ischemia (60 min) and reperfusion by temporary coronary occlusion
Comparison
Sevoflurane anesthetic preconditioning vs Infarcted without sevoflurane and non-infarcted…
Design
Preclinical
Follow-up
21 days
Authors
Discussion
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Implication
Should not change clinical practice; hypothesis-generating for sevoflurane preconditioning in human ischemia-reperfusion.
Structured PICO
Does sevoflurane preconditioning improve cardiac function and autonomic modulation in rats undergoing myocardial ischemia-reperfusion?
P
Population
20 Wistar rats subjected to myocardial ischemia and reperfusion, followed for 21 days.
I
Intervention
Sevoflurane anesthetic preconditioning
C
Comparator
Infarcted without sevoflurane (n=5) and non-infarcted control (n=10)
O
Outcome
Systolic and diastolic function, systolic arterial pressure variability, heart rate variability, and infarct size at 21 dayssurrogate
Sevoflurane preconditioning reduces infarct size and preserves cardiac and autonomic function in a rat model of myocardial ischemia-reperfusion.
Cite This Study
Pasqualin et al. (2016) studied Myocardial ischemia-reperfusion (n=20). Sevoflurane anesthetic preconditioning vs. Infarcted without sevoflurane and non-infarcted control was evaluated on Cardiac function, autonomic modulation, and infarct size. Sevoflurane preconditioning attenuated systolic and diastolic dysfunction, preserved vagal modulation of heart rate variability, and reduced infarct size in rats after myocardial ischemia-reperfusion.