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May 1, 2004Japanese Journal of Clinical OncologyOpen Access

Evaluation of Cardiotoxicity of a Combined Bolus plus Infusional 5-Fluorouracil/Folinic Acid Treatment by Echocardiography, Plasma Troponin I Level, QT Interval and Dispersion in Patients with Gastrointestinal System Cancers

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Why the study?

Does bolus plus infusional 5-fluorouracil/folinic acid treatment cause cardiotoxicity in patients with gastrointestinal system cancers?

Population

22 patients with gastrointestinal cancer

Design

Cohort

Follow-up

12 cycles of chemotherapy

Authors

İÖİlhan ÖztopDokuz Eylül University

Discussion

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Implication

QT prolongation with LV5FU2 may signal arrhythmia risk; leaves open whether ECG monitoring improves outcomes in GI cancers.

Structured PICO

Does bolus plus infusional 5-fluorouracil/folinic acid treatment cause cardiotoxicity in patients with gastrointestinal system cancers?

P
Population
22 patients with gastrointestinal cancer
I
Intervention
LV5FU2 regimen (bolus plus infusional 5-fluorouracil/folinic acid) chemotherapy for 12 cycles
O
Outcome
Cardiotoxicity evaluated by echocardiography, plasma troponin I (TnI) level, QT interval and QT dispersion on ECGsafety

The LV5FU2 chemotherapy regimen in gastrointestinal cancer patients is associated with significant QT interval prolongation, highlighting the need for ECG monitoring for potential malignant arrhythmias.

Limitations

  • needs longer follow-up
  • needs further detailed evaluations

Cite This Study

İlhan Öztop (2004) studied this question.

synapsesocial.com/papers/6a7de06a8b7e38892f150fa3https://doi.org/10.1093/jjco/hyh047

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Symptomatic Cardiotoxicity Associated with 5‐Fluorouracil1997 · 162 citations
  2. 2Corrected QT interval prolongation in anthracycline-treated survivors of childhood cancer.1993 · 97 citations
  3. 3Minor Increases in Plasma Troponin I Predict Decreased Left Ventricular Ejection Fraction after High-Dose Chemotherapy2003 · 125 citations
  4. 4The value of QT interval dispersion for identification of total mortality risk in non‐insulin‐dependent diabetes mellitus1998 · 102 citations
  5. 5QT and QTc dispersion are accurate predictors of cardiac death in newly diagnosed non-insulin dependent diabetes: cohort study1998 · 153 citations