Key result
The overall risk of cardiotoxicity with 5-fluorouracil and folinic acid was 3%, with a higher risk in patients with a history of cardiac disease (15.1% vs 1.5%).
Why the study?
Does the combination of 5-fluorouracil and folinic acid cause cardiotoxicity in patients with advanced gastrointestinal cancer?
Population
390 patients with advanced gastrointestinal cancer
Design
Cohort
Authors
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Prior cardiac disease may warrant closer 5-FU/folinic acid cardiotoxicity surveillance; observational data leave open causal inference and practice change.
Cohort (n=390)
Yes
Does the combination of 5-fluorouracil and folinic acid cause cardiotoxicity in patients with advanced gastrointestinal cancer?
The combination of 5-fluorouracil and folinic acid carries a 3% overall risk of cardiotoxicity, which is significantly elevated to 15.1% in patients with a prior history of cardiac disease.
Schöber et al. (1993) conducted a cohort in Advanced gastrointestinal cancer (n=390). 5-fluorouracil and folinic acid was evaluated on Cardiotoxicity. The overall risk of cardiotoxicity with 5-fluorouracil and folinic acid was 3%, with a higher risk in patients with a history of cardiac disease (15.1% vs 1.5%).
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