This case report and review highlights the histological and electron microscopic features of Kaposi's sarcoma, including Weibel-Palade granules suggesting endothelial origin, and rare pulmonary and bone marrow involvement.
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Hypothesis-generating for endothelial origin in Kaposi's sarcoma; leaves open clinical relevance of rare bone marrow and pulmonary involvement.
A case of Kaposi's sarcoma in a 60 year-old male was examined histologically and electron microscopically. Multiple hemorrhagic skin lesions were confined within the scalp. The major part of initial skin biopsies exhibited capillary hemangiomatous component, but examination of surgical materials confirmed its nature as hemorrhagic sarcoma. At autopsy, the skin lesions showed various histological pictures ranging from angiomatous or granulomatous to sarcomatous proliferation of spindle-shaped cells. Of intriguing findings were the bone marrow involvement and the pulmonary changes, the former consisting of typical sarcomatous lesion and the latter being characterized by purpuric appearance of the pleura responsible for the terminal pneumohemothorax. Electron microscopically, the tumor cells showed Weibel-Palade granules in the cytoplasm suggesting the endothelial nature. In this article, Japanese autopsy cases of Kaposi's sarcoma so far reported are summarized.
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Tsuyoshi Tange (1979) studied this question.
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