Idiopathic Paroxysmal Myoglobinuria

Case Reports1 October 1961Idiopathic Paroxysmal MyoglobinuriaDAVID E. COMINGS, M.D., HARRY ROSENFELD, M.D.DAVID E. COMINGS, M.D.Search for more papers by this author, HARRY ROSENFELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-647 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIdiopathic paroxysmal myoglobinuria is a rare syndrome consisting basically of the spontaneous onset of muscle pain and swelling followed by myoglobinuria and frequently complicated by oliguria or anuria due to myoglobininduced renal damage. The muscles most frequently affected are the muscles of the calf and the thigh, but abdominal, thoracic, cervical, masseter, and upper extremity muscle groups have also been involved. Associated symptoms in some cases include fever, chills, abdominal pain, diarrhea, vomiting, and pseudoparalysis of the affected muscle groups. Almost all of the reported cases have shown some degree of renal involvement, varying from albuminuria, cylindruria, and oliguria to...References1. MEYER-BETZ F: Beobachtungen an einem Eigenartigen mit Muskellahmungen Verbundenen Fall von Hamoglobinuria. Deutsch. Arch. Klin. Med. 101: 85, 1910. Google Scholar2. PAUL F: Uber einem Fall von Paralytischer Hämoglobinurie beim Menschen. Wien. Arch. Inn. Med. 7: 531, 1924. Google Scholar3. GUNTHER H: Kasuistische Mitteilung uber Myositis Myoglobinurica. Virchow. Arch. Path. Anat. 251: 141, 1924. CrossrefGoogle Scholar4. HITTMAIR A: Häemoglobinuria paroxysmalis paralytica. Wien. Klin. Wschr. 38: 431, 1925. Google Scholar5. DEBREGERNEZSEE RGG: Crises myopathiques paroxystiques avec hemoglobinurie. Bull. Soc. Med. Hop. Paris 50: 1640, 1934. Google Scholar6. 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SCHMIDHAMMAKER RL: Hereditary absence of muscle phosphorylase (McArdle's syndrome). New Engl. J. Med. 264: 223, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisReceived for publication May 17, 1960.From the Hekton Institute for Medical Research, Cook County Hospital, Chicago, Ill.Requests for reprints should be addressed to David E. Comings, M.D., Cook County Hospital, Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMuscle DiseasesMyoglobin: Methods and Diagnostic UsesMyoglobinuriaMyoglobinuriaIdiopathic Paroxysmal Myoglobinuria with Acute Renal Failure and HypercalcemiaMyoglobinuric Myopathy A Clinical, Histological, and Biochemical StudyCONSTANTINE L. HAMPERS, M.D., DAVID PRAGER, M.D.Genetics and diseases of muscleIdiopathic recurrent rhabdomyolysisMedical genetics 1961 1 October 1961Volume 55, Issue 4Page: 647-661KeywordsBlood pressureBlood urea nitrogenHemoglobinInflammationMusclesMyalgiaPaper electrophoresisTemperatureUrineWhite blood cells Issue Published: 1 October 1961 PDF DownloadLoading ...