Population
5 intact anesthetized dogs
Comparison
Increased or decreased aortic pressure via… vs Normal aortic pressure with spontaneous sinus…
Design
Preclinical
Authors
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Afterload alters EF and EDV in this model; leaves open translation to clinical load-adjusted interpretation.
Changes in outflow resistance significantly alter left ventricular volume and ejection fraction, highlighting the importance of circulatory state when evaluating these parameters.
Tsakiris et al. (1968) studied this question.
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