Why the study?
How do atrial and ventricular ectopic beats affect right and left ventricular stroke volumes and pressures in an open-chest dog model?
Population
Open-chest, anesthetized dogs
Comparison
Atrial and ventricular ectopic beats vs Normal sinus beats (control pressure)
Design
Preclinical
Authors
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Ectopy-induced ventricular imbalance in dogs warrants caution extrapolating to humans; leaves open mechanisms of output mismatch in clinical arrhythmias.
How do atrial and ventricular ectopic beats affect right and left ventricular stroke volumes and pressures in an open-chest dog model?
Ectopic beats cause unequal right and left ventricular ejection due to differences in diastolic pressures between the aorta and pulmonary artery, as well as differential pressure development in the stimulated ventricle.
Levy et al. (1962) studied this question.
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