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June 7, 2022Radiology

LA e-EAT above the mean (>33%) was associated with a higher risk of AF recurrence (HR, 2.1; 95% CI: 1.3, 3.3; P < .01).

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Why the study?

Left atrial enhancing epicardial adipose tissue (e-EAT) at cardiac CT may be a noninvasive surrogate marker for metabolic activity, but its relationship with recurrence after AF ablation was unknown.

Does left atrial enhancing epicardial adipose tissue (LA e-EAT) volume fraction predict 1-year AF recurrence in patients undergoing first AF ablation?

Population

212 consecutive patients undergoing first AF ablation

Comparison

LA e-EAT volume fraction above the mean (>33%) vs lower levels

Design

Secondary analysis of a prospective registry

Follow-up

1 year

Authors

AHA HuberSFSeverin FankhauserLCLaurève Chollet

Discussion

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Member takes

Overview

May support post-ablation risk stratification by LA e-EAT; leaves open prospective validation and therapeutic targeting.

Structured PICO

Does left atrial enhancing epicardial adipose tissue (LA e-EAT) volume fraction predict 1-year AF recurrence in patients undergoing first AF ablation?

P
Population
212 patients (mean age, 64 years; 159 men) undergoing first atrial fibrillation (AF) ablation (paroxysmal AF, 64%; persistent AF, 36%)
I
Intervention
Left atrial enhancing epicardial adipose tissue (LA e-EAT) volume fraction above the mean (>33%) measured by preprocedural noncontrast- and contrast-enhanced cardiac CT
C
Comparator
Left atrial enhancing epicardial adipose tissue (LA e-EAT) volume fraction below the mean (≤33%)
O
Outcome
1-year AF recurrence

Left atrial enhancing epicardial adipose tissue on cardiac CT is an independent predictor of atrial fibrillation recurrence after first ablation.

Cite This Study

Huber et al. (2022) studied this question.

synapsesocial.com/papers/6a7de57277b363cb17b87a4ehttps://doi.org/10.1148/radiol.212644
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MRI-quantified left atrial epicardial adipose tissue predicts atrial fibrillation recurrence following catheter ablation2022 · 13 citations
  2. 2Association Between Left Atrial Epicardial Adipose Tissue Attenuation Assessed by Cardiac Computed Tomography and Atrial Fibrillation Recurrence Following Catheter Ablation: A Systematic Review and Meta-Analysis2025 · 8 citations
  3. 3Epicardial Atrial Fat at Cardiac Magnetic Resonance Imaging and AF Recurrence after Transcatheter Ablation2024 · 3 citations
  4. 4Epicardial Atrial Fat at Cardiac Magnetic Resonance Imaging and AF Recurrence after Transcatheter Ablation2023 · 6 citations
  5. 5Association Between Epicardial Adipose Tissue Volumes on 3-Dimensional Reconstructed CT Images and Recurrence of Atrial Fibrillation After Catheter Ablation2011 · 140 citations