Population
Wild-type and homozygous p53 knockout male mice and isolated neonatal mouse cardiac fibroblasts.
Comparison
p53 deficiency or p53 overexpression subjected… vs Wild-type mice or scrambled siRNA/Ad-GFP…
Design
Preclinical, double-blind fashion (for cell counting)
Follow-up
7 days post-operation
Authors
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p53-senescence axis may limit post-MI fibrosis in mice; leaves open whether inhibition aids human cardiac repair.
Inhibition of p53-mediated fibroblast senescence enhances reparative cardiac fibrosis after myocardial infarction in a mouse model.
Li et al. (2013) studied this question.
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