Why the study?
Is there a link between malignant hyperthermia and exertional heat illness?
Is there a link between malignant hyperthermia and exertional heat illness?
This review highlights a potential genetic link between malignant hyperthermia and exertional heat illness, suggesting a role for ryanodine receptor gene screening.
Does not support routine genetic screening for exertional heat illness; leaves open a potential ryanodine receptor link requiring prospective validation.
In Brief MULDOON, S., P. DEUSTER, B. BRANDOM, and R. BUNGER. Is there a link between malignant hyperthermia and exertional heat illness? Exerc. Sport Sci. Rev., Vol. 32, No. 4, pp. 174–179, 2004. Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions. It has been suggested that a subset of MH susceptible persons may be predisposed to EHI. We examine the current understanding of these disorders and explore evidence of a relationship. Screening for the muscle type I ryanodine receptor gene should help clarify the relationship between MH and EHI. An examination of the relationship between exertional heat illness and malignant hyperthermia is presented.
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Muldoon et al. (2004) studied this question.
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