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January 8, 1953New England Journal of Medicine

The Relation of Heart Size to the Time Intervals of the Heart Beat, with Particular Reference to the Elephant and the Whale

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Population

Healthy newborn infants and full-grown adults, as well as elephants and whales

Design

Other

Authors

PWPaul D. WhiteUniversity of the West of EnglandRKRobert L. KingLipscomb UniversityJJJames L. JenksHeart Foundation

Discussion

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Implication

Guides age-specific ECG interpretation in pediatrics and adults; leaves open validation across disease states and species.

Structured PICO

P
Population
Healthy newborn infants and full-grown adults, as well as elephants and whales
O
Outcome
Normal upper limit of the atrioventricular conduction time (PR interval) and duration of the spread of the excitation wave through the ventricles (QRS complex)surrogate

This comparative physiology paper discusses the relationship between heart size and electrocardiographic time intervals across human developmental stages and large mammals.

Cite This Study

White et al. (1953) studied this question.

synapsesocial.com/papers/6a7de9fecf7e8b32dacb5906https://doi.org/10.1056/nejm195301082480207
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantitative Clinical Chemistry.1932 · 839 citations
  2. 2The Physiology of the Elephant1937 · 87 citations