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July 4, 2005British journal of surgeryOpen Access

Preoperative plasma N-terminal pro-brain natriuretic peptide as a marker of cardiac risk in patients undergoing elective non-cardiac surgery

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Why the study?

Does preoperative plasma NTproBNP level predict postoperative cardiac complications in patients undergoing elective non-cardiac surgery?

Population

190 consecutive patients undergoing elective non-cardiac surgery requiring general anaesthesia

Design

Cohort

Follow-up

Postoperative period

Authors

HLH-P LauNational Taiwan University HospitalJLJ-M LinMinistry of Health and WelfareMWM-J WangNational Taiwan University Hospital

Discussion

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Implication

May support preoperative risk stratification; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does preoperative plasma NTproBNP level predict postoperative cardiac complications in patients undergoing elective non-cardiac surgery?

P
Population
190 consecutive patients undergoing elective non-cardiac surgery requiring general anaesthesia
I
Intervention
Preoperative plasma NTproBNP measurement
O
Outcome
Postoperative cardiac complications (composite of cardiac death, acute coronary syndrome, heart failure and haemodynamic compromise from cardiac arrhythmias)composite

Preoperative NTproBNP > 450 ng/l is a highly sensitive and specific independent predictor of postoperative cardiac complications in patients undergoing elective non-cardiac surgery.

Cite This Study

Lau et al. (2005) studied this question.

synapsesocial.com/papers/6a7deb21da6d5413e2cb5e35https://doi.org/10.1002/bjs.4947
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Echocardiography for Assessing Cardiac Risk in Patients Having Noncardiac Surgery1996 · 217 citations
  2. 2NT-proBNP: a new diagnostic screening tool to differentiate between patients with normal and reduced left ventricular systolic function2003 · 219 citations
  3. 3The influence of age, sex and other variables on the plasma level of N-terminal pro brain natriuretic peptide in a large sample of the general population2003 · 354 citations
  4. 4Plasma cardiac natriuretic peptide determination as a screening test for the detection of patients with mild left ventricular impairment.1996 · 155 citations
  5. 5Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure.1993 · 618 citations