Why the study?
Enteroviruses can cause acute flaccid paralysis, and specific non-polio enteroviruses have been described in polio-like residual paralytic events.
The study highlights a high diversity of non-polio enteroviruses in Ugandan patients with acute flaccid paralysis, identifying specific viral types associated with residual paralysis.
Certain NPEV types may link to residual paralysis in AFP; hypothesis-generating and requires prospective validation before guiding surveillance.
Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AFP patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed and thirty one NPEV types were identified of which 91% were Enterovirus B and 9% were Enterovirus A species. The NPEVs were distributed across the country with most patients in the eastern region (41/89; 46.1%). The highest proportion of patients were children less than 5 years (77/89; 86.5%) and male patients were more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently observed and phylogenetic analysis of these sequences revealed high diversity. Coxsackievirus B5 (CV-B5), CV-B6, E21, and EV-B69 were only seen in patients with residual paralysis. Analyses of the EV-A71 sequence indicated a unique genogroup.
No takes yet. Share an insight, caveat, or question.
Tushabe et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: