Key result
Non-polio enteroviruses were detected in 25% of stool samples from children with acute flaccid paralysis, including the identification of a novel serotype EV-B106 and a distinct genotype of EV-B93.
Cross-Sectional (n=184)
The study identifies high genetic diversity of non-polio enteroviruses, including novel serotypes EV-B93 and EV-B106, in acute flaccid paralysis patients in Pakistan.
Surveillance for non-polio enteroviruses in pediatric AFP should continue; leaves open their etiologic role pending controlled studies.
Non-polio enteroviruses (NPEVs) are among the most common viruses infecting humans worldwide. Most of these infections are asymptomatic but few can lead to systemic and neurological disorders like Acute Flaccid Paralysis (AFP). Acute Flaccid Paralysis is a clinical syndrome and NPEVs have been isolated frequently from the patients suffering from AFP but little is known about their causal relationship. The objective of this study was to identify and characterize the NPEV serotypes recovered from 184 stool samples collected from AFP patients in Federally Administered Tribal Areas (FATA) in north-west of Pakistan. Overall, 44 (95.6 %) isolates were successfully typed through microneutralization assay as a member of enterovirus B species including echovirus (E)-2, E-3, E-4, E-6, E-7, E-11, E-13, E-14, E-21 and E-29 while two isolates (PAK NIH SP6545B and PAK NIH SP1202B) remained untypeable. The VP1 and capsid regions analysis characterized these viruses as EV-B93 and EV-B106. Phylogenetic analysis confirmed that PAK NIH isolates had high genetic diversity and represent distinct genotypes circulating in the country. Our findings highlight the role of NPEVs in AFP cases to be thoroughly investigated especially in high disease risk areas, with limited surveillance activities and health resources.
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Shaukat et al. (2013) conducted a cross-sectional in Acute Flaccid Paralysis (n=184). Non-polio enterovirus infection was evaluated on Detection and characterization of non-polio enteroviruses. Non-polio enteroviruses were detected in 25% of stool samples from children with acute flaccid paralysis, including the identification of a novel serotype EV-B106 and a distinct genotype of EV-B93.
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