July 1, 2002The FASEB Journal

Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size

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Why the study?

Do ligands of PPAR-gamma and PPAR-alpha reduce myocardial infarct size in a rat model of acute myocardial infarction?

Population

Rat model of acute myocardial infarction and freshly isolated rat cardiac myocytes and fibroblasts

Design

Preclinical

Authors

NWNicole S. WaymanUniversity of Messina YHYoshiyuki HattoriToyohashi University of Technology MMMichelle C. McDonaldUniversity of London

Discussion

Member takes

Implication

Hypothesis-generating in rat ischemia-reperfusion; does not support clinical use in acute MI.

Structured PICO

Do ligands of PPAR-gamma and PPAR-alpha reduce myocardial infarct size in a rat model of acute myocardial infarction?

Population

Rat model of acute myocardial infarction (regional myocardial ischemia and reperfusion in vivo) and freshly isolated rat cardiac myocytes and fibroblasts

Intervention

Ligands of PPAR-gamma (rosiglitazone, ciglitazone, pioglitazone, 15D-PGJ2, PGA1) and PPAR-alpha (clofibrate, WY 14643)

Outcome

Myocardial infarct sizesurrogate

Ligands of PPAR-gamma and PPAR-alpha, particularly 15D-PGJ2, reduce myocardial infarct size and inflammatory markers in a rat model of ischemia-reperfusion injury.

Cite This Study

Wayman et al. (2002) studied this question.

synapsesocial.com/papers/6a7dee2c4d9a7e00d75ca667 https://doi.org/10.1096/fj.01-0793com

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Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ligands of the peroxisome proliferator‐activated receptors (PPAR‐γ and PPAR‐α) reduce myocardial infarct size

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider