Why the study?
What are the pharmacokinetics of ropivacaine administered by 72-h epidural infusion for postoperative analgesia after major orthopedic surgery?
What are the pharmacokinetics of ropivacaine administered by 72-h epidural infusion for postoperative analgesia after major orthopedic surgery?
Postoperative increases in plasma alpha1-acid glycoprotein concentrations enhance the protein binding of ropivacaine and its metabolite, causing divergence of total and unbound plasma concentrations.
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Steady unbound ropivacaine levels during 72-h epidural infusion may indicate low toxicity risk; hypothesis-generating for AAG effects on postoperative PK.
Burm et al. (2000) studied this question.
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