Why the study?
Does continuous extrapleural infusion of ropivacaine 0.2% at 6 or 9 mL/h result in toxic plasma concentrations in adults undergoing cardiovascular surgery via lateral thoracotomy?
Population
17 consenting adults scheduled for elective cardiovascular surgery, with or without extracorporeal bypass…
Comparison
Continuous extrapleural infusion of ropivacaine… vs Continuous extrapleural infusion of ropivacaine…
Design
RCT, randomly assigned, nonblinded
Follow-up
48 hours
Authors
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Requires caution with continuous extrapleural ropivacaine post-thoracotomy; challenges presumed safety and dose proportionality of standard regimens.
Does continuous extrapleural infusion of ropivacaine 0.2% at 6 or 9 mL/h result in toxic plasma concentrations in adults undergoing cardiovascular surgery via lateral thoracotomy?
Continuous extrapleural infusion of ropivacaine 0.2% at 6 or 9 mL/h after cardiovascular surgery can lead to unpredictable and potentially toxic plasma concentrations.
Maurer et al. (2007) studied this question.
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