What question did this study set out to answer?

To evaluate hypothalamo-pituitary-adrenal (HPA) axis function across stages of HIV infection and examine the relationship between hormone levels and CD4 cell counts.

February 1, 1996The Journal of Clinical Endocrinology & MetabolismOpen Access

Hypothalamo-pituitary-adrenal function in human immunodeficiency virus-infected men.

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Authors

OLOlivier LortholaryHôpital Pellegrin NCN. ChristeffCentre National de la Recherche Scientifique PCP CasassusHôpital Avicenne

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Implication

Prospective study reveals elevated cortisol and impaired corticotropin-releasing hormone response in advanced HIV-infected men, indicating central hypothalamo-pituitary-adrenal dysregulation.

Key Points

To evaluate hypothalamo-pituitary-adrenal (HPA) axis function across stages of HIV infection and examine the relationship between hormone levels and CD4 cell counts.
Prospectively evaluated adrenal function in 51 HIV-positive men categorized into CDC stages II/III or IVC.
Measured basal serum concentrations of cortisol, progesterone, and 17 alpha-hydroxyprogesterone, alongside circadian rhythms of ACTH and cortisol in 22 stage IVC patients.
Administered ovine corticotropin-releasing hormone (oCRH) and cosyntropin stimulation tests in stage IVC patients, correlating all hormone concentrations with CD4 cell counts.
Mean serum cortisol in stage IVC was significantly higher than controls (P < 0.0001) and stage II/III patients (P < 0.004), while progesterone was elevated in stages II/III and IVC (both P < 0.0001), and 17 alpha-hydroxyprogesterone was elevated in stage II/III (P < 0.002 vs controls; P < 0.02 vs stage IVC).
Cosyntropin stimulation tests were normal in stage IVC patients, but 63% (14 of 22) demonstrated reduced or blunted responses to oCRH stimulation.
Absolute CD4 cell counts demonstrated a significant negative correlation with serum cortisol concentrations across all subjects (P < 0.02).

Cite This Study

Lortholary et al. (1996) studied this question.

synapsesocial.com/papers/6a7defebc6a151781133a97a https://doi.org/10.1210/jcem.81.2.8636305

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Implication

Prospective study reveals elevated cortisol and impaired corticotropin-releasing hormone response in advanced HIV-infected men, indicating central hypothalamo-pituitary-adrenal dysregulation.

Hypothalamo-pituitary-adrenal function in human immunodeficiency virus-infected men.

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Implication

Key Points

Cite This Study

Hypothalamo-pituitary-adrenal function in human immunodeficiency virus-infected men.

Discussion

Member takes

Implication

Key Points

Cite This Study

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