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April 29, 2021The FASEB JournalOpen Access

CIDEC gene silencing significantly ameliorated metabolic disturbance, insulin resistance, myocardial hypertrophy, interstitial fibrosis, ectopic lipid deposition, inflammation, and cardiac dysfunction in DCM rats via enhanced AMPKα activation.

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Why the study?

CIDEC mediates metabolic disturbance and insulin resistance, but whether it plays a critical role in diabetic cardiomyopathy remained to be investigated.

Does CIDEC gene silencing alleviate diabetic cardiomyopathy in preclinical models?

Population

Rat model of diabetic cardiomyopathy and in vitro insulin-resistant cardiac fibroblasts

Comparison

CIDEC gene silencing vs unsilenced models

Design

Preclinical in vivo animal and in vitro cellular study

Authors

HZHuimin ZhouYTYun TiHWHui Wang

Discussion

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Overview

CIDEC silencing merits translational study in diabetic cardiomyopathy; hypothesis-generating in animal models only.

Structured PICO

Does CIDEC gene silencing alleviate diabetic cardiomyopathy in preclinical models?

P
Population
Diabetic cardiomyopathy (DCM) rat model induced by a high-fat diet and a single injection of low-dose streptozotocin (27.5 mg/kg), and an in vitro insulin-resistant cardiac fibroblast (CF) model induced by high glucose (15.5 mmol/L) and high insulin (10^4 μU/mL).
I
Intervention
CIDEC gene silencing
C
Comparator
Unsilenced DCM rats and cardiac fibroblasts (implied control)
O
Outcome
Cardiac function, myocardial hypertrophy, interstitial fibrosis, ectopic lipid deposition, inflammation, and metabolic parameterssurrogate

CIDEC gene silencing alleviates diabetic cardiomyopathy via AMPKα signaling in vivo and in vitro, suggesting it may be a promising therapeutic target.

Cite This Study

Zhou et al. (2021) studied this question.

synapsesocial.com/papers/6a7df0ce6bb6a3a5bcac8295https://doi.org/10.1096/fj.202002562r
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial-Specific Expression of CIDEC Improves High-Fat Diet–Induced Vascular and Metabolic Dysfunction2022 · 13 citations
  2. 2Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy2022 · 15 citations
  3. 3Cardiac fibroblast-derived CCN1 aggravates diabetic cardiomyopathy through ITGAV-ITGB1/integrin αvβ1-mediated autophagy inhibition2026
  4. 4Intermedin Alleviates Diabetic Cardiomyopathy by Up-Regulating CPT-1β through Activation of the Phosphatidyl Inositol 3 Kinase/Protein Kinase B Signaling Pathway2024 · 1 citations
  5. 5Cinnamaldehyde Attenuates Diabetic Cardiomyopathy by Ameliorating Energy Metabolism Disturbance and Activating Autophagy2025 · 5 citations