Why the study?
Despite successful myocardial regeneration in animal models, recent meta-analyses report no significant long-term regeneration with autologous stem cell therapy in acute myocardial infarction patients, likely due to an inhibitory inflammatory microenvironment.
Design
Review
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May hinder stem cell therapy efficacy in AMI; leaves open whether anti-inflammatory adjuncts improve outcomes in trials.
The inflammatory microenvironment in acute myocardial infarction is a major barrier to the success of stem cell therapy, suggesting that anti-inflammatory strategies or modified cells are needed to improve regenerative outcomes.
Khodayari et al. (2019) studied this question.
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