Population
Rats subjected to myocardial ischemia followed by 5 min of reperfusion.
Comparison
Diazepam with ketamine hydrochloride or urethane… vs Pentobarbital (60 mg/kg) anesthesia
Design
Preclinical
Follow-up
5 minutes of reperfusion
Authors
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Anesthesia choice may confound reperfusion arrhythmia rates in rat I/R models; leaves open optimal protocols for arrhythmia versus hemodynamic studies.
In rat models of ischemia/reperfusion, pentobarbitone anesthesia is recommended for studying arrhythmias, whereas a diazepam and ketamine combination is better suited for hemodynamic investigations.
Baczkó et al. (1997) studied this question.
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