January 11, 2010Virology JournalOpen Access

Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress

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Population

Swine umbilical vein endothelial cell line (SUVEC) and porcine kidney cells (PK-15)

Comparison

Expression of Classical swine fever virus NS2… vs Control cells

Design

Preclinical

Follow-up

up to 96 hours (in vitro)

Authors

QTQinghai TangChinese Academy of Sciences YZYanming ZhangGas Technology Institute LFLi FanJiangxi University of Traditional Chinese Medicine

Discussion

Member takes

Implication

NS2 effects on cell cycle remain hypothesis-generating in vitro; leaves open validation in CSFV animal models.

Structured PICO

Population

Swine umbilical vein endothelial cell line (SUVEC) and porcine kidney cells (PK-15)

Intervention

Expression of Classical swine fever virus (CSFV) NS2 protein (GFP-NS2 and NS2-GFP fusion proteins)

Comparator

Control cells (pEGFP-C1 transfected and untransfected cells)

Outcome

Cell growth, cell cycle progression, subcellular localization of NS2, ER stress, and NF-kappaB activationsurrogate

CSFV NS2 protein localizes to the endoplasmic reticulum and modulates cellular growth by inducing S-phase arrest and ER stress, likely providing a favorable environment for viral replication.

Cite This Study

Tang et al. (2010) studied this question.

synapsesocial.com/papers/6a7df14d33dcb27c99cb624a https://doi.org/10.1186/1743-422x-7-4

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Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider