Why the study?
Do verapamil and lisinopril improve myocardial tolerance to acute ischemia-reperfusion injury in isolated rabbit hearts?
Do verapamil and lisinopril improve myocardial tolerance to acute ischemia-reperfusion injury in isolated rabbit hearts?
In an isolated rabbit heart model, verapamil increased coronary flow while lisinopril improved contractility and heart rate during ischemia-reperfusion.
Should not change clinical practice; hypothesis-generating for verapamil and lisinopril in ischemia-reperfusion.
This work aims to clarify the role of calcium channel blocker (verapamil) and angiotensin-converting enzyme inhibitor (lisinopril) on myocardial is-chaemia reperfusion injury. The study was done using isolated rabbits hearts and Langendroffs apparatus for recording myocardial contractility, heart rate and coronary flow, also glucose uptake by coronary slices was estimated by glucose enzymatic kit. The work included 4 groups; Group A to study effect of ischaemia and reperfusion on mentioned parameters, Group B to study effect of verapamil and lisinopril on tested parameters, Group C to study the effect of 5 minutes preischaemia administration of verapamil and lisinopril on tested parameters and Group D to study the effects of administration of verapamil and lisinopril with reperfusion on parameters mentioned before. Results concluded that global ischaemia decreased the myocardial contractility and heart rate but increases glucose uptake, verapamil is a potent drug used to decrease myocardial contractility, heart rate and increase coronary flow in ischaemic hearts. Lisinopril is a drug of choice to improve contractility and heart rate when administered preischaemic or with reperfusion.
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Serougy et al. (2006) studied this question.
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