Population
4 carotid plaque samples removed at endarterectomy
Comparison
Numerical models for mechanical analysis based… vs Neovessels without red blood cells present nearby
Design
Preclinical
Authors
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Suggests mechanical overload promotes neovessel rupture; hypothesis-generating in animals, leaves open human relevance.
Local critical mechanical conditions, specifically increased stress and stretch, may lead to neovessel rupture and promote intraplaque hemorrhage in carotid atherosclerosis.
Teng et al. (2012) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: