Population
Saccharomyces cerevisiae (yeast) strains and RNA 3'-end processing extracts
Comparison
PAN-deficient yeast strains / extracts lacking PAN vs Wild-type yeast strains / extracts containing PAN
Design
Preclinical
Authors
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PAN controls poly(A) tail length via deadenylation in yeast; leaves open conservation and roles in mammalian mRNA regulation.
The Pab1p-dependent poly(A) nuclease (PAN) is required for the initial phase of mRNA deadenylation to control message-specific poly(A) tail lengths in yeast.
Brown et al. (1998) studied this question.
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